2-氟-4-硝基苯甲酸叔丁酯合成路线 （共 9 条）
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=10 - 20°C; 2 h;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/143649 A2, 2008 ;
Location in patent: Page/Page column 49-50 ;
反应条件
1: SOCl2 / CH2Cl2 2: tetrahydrofuran View Scheme
参考文献
Pharmacia and Upjohn Company
Patent: US6441005 B1, 2002 ;
反应条件
1: CrO3; AcOH 2: SOCl2 / CH2Cl2 3: tetrahydrofuran View Scheme
参考文献
Gordeev, Mikhail F.; Hackbarth, Corinne; Barbachyn, Michael R.; Banitt, Lee S.; Gage, James R.; Luehr, Gary W.; Gomez, Marcela; Trias, Joaquim; Morin, Sara E.; Zurenko, Gary E.; Parker, Christian N.; Evans, Jonathan M.; White, Richard J.; Patel, Dinesh V.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4213 - 4216
反应条件
n-butyllithium 1.) hexane, 20 deg C, 20 min, 2.) hexane, THF, 22 h; Yield given. Multistep reaction;
参考文献
Springer; Niculescu-Duvaz; Pedley
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2361 - 2370
反应条件
pyridine; p-toluenesulfonyl chloride 1.) 15 deg C, 5 min, 2.) RT, 2.5 h; Yield given. Multistep reaction;
参考文献
Marsham; Jackman; Barker; Boyle; Pegg; Wardleworth; Kimbell; O'Connor; Calvert; Hughes
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 994 - 1004
参考文献
Gordeev, Mikhail F.; Hackbarth, Corinne; Barbachyn, Michael R.; Banitt, Lee S.; Gage, James R.; Luehr, Gary W.; Gomez, Marcela; Trias, Joaquim; Morin, Sara E.; Zurenko, Gary E.; Parker, Christian N.; Evans, Jonathan M.; White, Richard J.; Patel, Dinesh V.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4213 - 4216
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=30°C; P=22501.8 Torr; 20 h;
参考文献
Marsham; Jackman; Barker; Boyle; Pegg; Wardleworth; Kimbell; O'Connor; Calvert; Hughes
Journal of Medicinal Chemistry, 1995 , vol. 38, # 6 p. 994 - 1004
反应条件
ammonium chloride in ethanol; water
参考文献
Pharmacia and Upjohn Company
Patent: US6239152 B1, 2001 ;
反应条件
1: Fe; aq. NH4Cl 2: pyridine / CH2Cl2 View Scheme
参考文献
Gordeev, Mikhail F.; Hackbarth, Corinne; Barbachyn, Michael R.; Banitt, Lee S.; Gage, James R.; Luehr, Gary W.; Gomez, Marcela; Trias, Joaquim; Morin, Sara E.; Zurenko, Gary E.; Parker, Christian N.; Evans, Jonathan M.; White, Richard J.; Patel, Dinesh V.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4213 - 4216
