3-羟基-N,N-二甲基苯甲酰胺合成路线 （共 7 条）
反应条件
methanol; potassium carbonate T=20°C; 5 h;
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore
Patent: WO2012/101654 A2, 2012 ;
Location in patent: Page/Page column 68-69 ;
WO 2012/101654 A2
反应条件
N-ethyl-N,N-diisopropylamine; HATU in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
PFIZER INC.; ASPNES, Gary Erik; DIDIUK, Mary Theresa; GUZMAN-PEREZ, Angel; MAGUIRE, Robert John
Patent: WO2011/158149 A1, 2011 ;
Location in patent: Page/Page column 75 ;
WO 2011/158149 A1
反应条件
1: SOCl2 View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore
Patent: WO2012/101654 A2, 2012 ;
WO 2012/101654 A2
反应条件
1: pyridine / 4 h / 20 °C 2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C 3: dichloromethane; tetrahydrofuran / 0 - 20 °C 4: potassium carbonate; methanol / 5 h / 20 °C View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore
Patent: WO2012/101654 A2, 2012 ;
WO 2012/101654 A2
反应条件
1: dichloromethane; tetrahydrofuran / 0 - 20 °C 2: potassium carbonate; methanol / 5 h / 20 °C View Scheme
参考文献
SPHAERA PHARMA PVT. LTD; DUGAR, Sundeep; MAHAJAN, Dinesh; DEOKAR, Rhushikesh, Chandraban; HOLLINGER, Frank, Peter; KAPOOR, Kamal, Kishore
Patent: WO2012/101654 A2, 2012 ;
WO 2012/101654 A2
反应条件
phosphorus pentoxide
参考文献
Schindlbauer,H.
Monatshefte fuer Chemie, 1968 , vol. 99, p. 1799 - 1807
Full Text View citing articles Show Details
Ronald, Robert C.; Winkle, Mark R.
Tetrahedron, 1983 , vol. 39, # 12 p. 2031 - 2042
参考文献
Tilly,G.
Chimica Therapeutica, 1967 , vol. 2, p. 57 - 65
