3-(4-氟苯氧基)丙酸合成路线 （共 12 条）
反应条件
hydrogenchloride; formic acid 4 h; Heating;
参考文献
Sarges; Bordner; Dominy; Peterson; Whipple
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1716 - 1720
参考文献
Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
反应条件
1: sulfuric acid; sodium nitrite; phosphoric acid / Erhitzen des Reaktionsgemisches mit Kupfer(II)-sulfat und wss. Schwefelsaeure auf 140grad 2: aq. NaOH solution View Scheme
参考文献
Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
反应条件
2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; [bis(acetoxy)iodo]benzene in water; acetonitrile T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317
反应条件
1: 81 percent / 40percent N-benzyltrimethylammonium hydroxide in methanol (Triton B) / 39 h / Heating 2: 84 percent / HCl, 97percent HCO2H / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
反应条件
sodium hydroxide in water Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317
反应条件
sulfuric acid T=20°C; 12 h;
参考文献
Yang, Geng-Liang; Song, Ya-Li; Liu, Xiao-Ming; Yang, Ning
Asian Journal of Chemistry, 2013 , vol. 25, # 4 p. 1849 - 1852
反应条件
PPA 0.333333 h; Heating;
参考文献
Sarges; Bordner; Dominy; Peterson; Whipple
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1716 - 1720
反应条件
1: 83 percent / polyphosphoric acid / 0.33 h / Heating 2: 64 percent / (NH4)2CO3 / H2O; ethanol / 63 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 11 p. 1716 - 1720
反应条件
borane in tetrahydrofuran; water
