3-(4-氟苯氧基)丙酸合成路线 (共 12 条)
反应条件
1: With oxalyl dichloride T=0°C; Friedel-Crafts Acylation; 2: With AlCl3, aluminium chloride in dichloromethane T=20°C; Friedel-Crafts Acylation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 1 p. 310 - 317
反应条件
1: 83 percent / polyphosphoric acid / 0.33 h / Heating
2: 64 percent / (NH4)2CO3 / H2O; ethanol / 63 h / 65 °C
View Scheme
参考文献
Sarges; Bordner; Dominy; Peterson; Whipple
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1716 - 1720