1.1: methanol / 20 °C 2.1: sodium hydroxide / methanol; water / 17 h / 0 °C 3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 16 h / 20 °C 4.1: trichlorophosphate / toluene / 16 h / |Reflux 4.2: 6 h / -78 °C 5.1: hydrogen; palladium(II) oxide hydrate / ethyl acetate; methanol; water / 23 h / 20 °C 6.1: ammonia; sodium / 1,4-dioxane / 2 h / -78 °C View Scheme

1.1: methanol / 20 °C 2.1: sodium hydroxide / methanol; water / 17 h / 0 °C 3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 16 h / 20 °C 4.1: trichlorophosphate / toluene / 16 h / |Reflux 4.2: 6 h / -78 °C 5.1: hydrogen; palladium(II) oxide hydrate / ethyl acetate; methanol; water / 23 h / 20 °C 6.1: ammonia; sodium / 1,4-dioxane / 2 h / -78 °C View Scheme

1.1: methanol / 20 °C 2.1: sodium hydroxide / methanol; water / 17 h / 0 °C 3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 16 h / 20 °C 4.1: trichlorophosphate / toluene / 16 h / |Reflux 4.2: 6 h / -78 °C 5.1: hydrogen; palladium(II) oxide hydrate / ethyl acetate; methanol; water / 23 h / 20 °C 6.1: ammonia; sodium / 1,4-dioxane / 2 h / -78 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2037554', constants.ctx, '0')">sulfuric acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />&nbsp;Electrochemical reaction;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: tetrabutyl-ammonium chloride; hydrogenchloride / water; acetonitrile / |Electrochemical reaction<br />2: |Electrochemical reaction<br />3: |Electrochemical reaction<br />4: sulfuric acid / methanol; water / |Electrochemical reaction<br /> <br /> &nbsp;