1: 68 percent / NaClO2, NaH2PO4, H2O2 / H2O; acetonitrile / 0 - 10 °C 2: 60 percent / PTSA / CHCl3 View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4921393', constants.ctx, '0')">ozone</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '610776', constants.ctx, '0')">triphenylphosphine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-78&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 85 percent / triphenyl phosphine, CCl₄ / 80 &deg;C<br />2: 88 percent / sodium sand / diethyl ether / Ambient temperature<br />3: 79 percent / imidazole / dimethylformamide<br />4: O₃, triphenyl phospine / CH₂Cl₂ / -78 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 75 percent / (-)-DIPT, TBHP, TIP / CH₂Cl₂ / 2 h / -20 &deg;C<br />2: 85 percent / triphenyl phosphine, CCl₄ / 80 &deg;C<br />3: 88 percent / sodium sand / diethyl ether / Ambient temperature<br />4: 79 percent / imidazole / dimethylformamide<br />5: O₃, triphenyl phospine / CH₂Cl₂ / -78 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 74 percent / DIBAL-H / CH₂Cl₂ / -10 &deg;C<br />2: 75 percent / (-)-DIPT, TBHP, TIP / CH₂Cl₂ / 2 h / -20 &deg;C<br />3: 85 percent / triphenyl phosphine, CCl₄ / 80 &deg;C<br />4: 88 percent / sodium sand / diethyl ether / Ambient temperature<br />5: 79 percent / imidazole / dimethylformamide<br />6: O₃, triphenyl phospine / CH₂Cl₂ / -78 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 8 steps<br /> </b>1: 78 percent / benzene / 80 &deg;C<br />2: 87 percent / imidazole / dimethylformamide<br />3: 74 percent / DIBAL-H / CH₂Cl₂ / -10 &deg;C<br />4: 75 percent / (-)-DIPT, TBHP, TIP / CH₂Cl₂ / 2 h / -20 &deg;C<br />5: 85 percent / triphenyl phosphine, CCl₄ / 80 &deg;C<br />6: 88 percent / sodium sand / diethyl ether / Ambient temperature<br />7: 79 percent / imidazole / dimethylformamide<br />8: O₃, triphenyl phospine / CH₂Cl₂ / -78 &deg;C<br /> <br /> &nbsp;