1: (S)-1,2,3,4-tetrahydro-2-naphthoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 10 h; 2: magnesium salt of monomethyl malonic acid in tetrahydrofuran T=20°C; 18 h; Further stages.;

sodium hydride T=25 - 100°C; Inert atmosphere;

1: potassium dimethylmalonate With triethylamine; magnesium chloride in acetonitrile T=20°C; 4 h; 2: N-(2'-naphthoyl)imidazole in acetonitrile T=20°C;

1.1: tetrahydrofuran / 20 °C 2.1: magnesium chloride; triethylamine / acetonitrile / 4 h / 20 °C 2.2: 11.3 g / acetonitrile / 20 °C View Scheme