aminomethyl resin-supported N-propylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 1 h;

1: sodium allyloxide / tetrahydrofuran / Ambient temperature 2: 88 percent / HCO2H, Et3N, PPh3 / Pd2(DBA)3CHCl3 / dioxane / 8 h / Ambient temperature View Scheme

sodium hydride; allyl alcohol in tetrahydrofuran 4 h; Ambient temperature;

boron tribromide; N-ethyl-N,N-diisopropylamine; N,N'-[(1S,2S)-1,2-diphenylethane-1,2-diyl]bis[3,5-bis(trifluoromethyl)-benzenesulfonamide] in dichloromethane 1.) -78 deg C, 24 h, 2.) -20 deg C, 14 d; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

polymethylhydrosiloxane in toluene T=110°C; Inert atmosphere;

1: 73 percent / NaH, allyl alcohol / tetrahydrofuran / 4 h / Ambient temperature 2: 80 percent / formic acid, Et3N, <Ru(1,5-cyclooctadiene)(OCOCF3)2>2, 1,4-bis(diphenylphosphino)butane / dioxane / 4 h / Heating View Scheme