[(2R,3S,4S,5R,6S)-6-[(2S)-2,3-二(棕榈酰氧基)丙氧基]-3,4,5-三羟基四氢吡喃-2-基]甲基2-三甲基铵乙基磷酸酯盐合成路线 （共 6 条）
反应条件
Pearlman's catalist; hydrogen; acetic acid in methanol T=20°C; P=760.051 Torr; 7 h;
参考文献
Nishida, Yoshihiro; Shingu, Yuko; Mengfei, Yuan; Fukuda, Kazuo; Dohi, Hirofumi; Matsuda, Sachie; Matsuda, Kazuhiro
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 629 - 639
反应条件
1.1: carbon tetrabromide; triphenylphosphine / N,N-dimethyl-formamide / 3 h / 20 °C 1.2: 14 h / 20 °C 2.1: pyridine; 4-(N,N-dimethlyamino)pyridine / 12 h / 20 °C 3.1: pyridine / 3 h / 20 °C 4.1: trifluoroacetic acid / methanol; dichloromethane / 2 h / 20 °C 5.1: 2-cyanoethyl N,N,N',N'-tetra-isopropylphosphorodiamidite / dichloromethane / 2 h / 20 °C / Inert atmosphere; Molecular sieve 5.2: 1.5 h / 20 °C 5.3: 0.17 h / 0 - 20 °C 6.1: Pearlman's catalist; hydrogen; acetic acid / methanol / 7 h / 20 °C / 760.05 Torr View Scheme
参考文献
Nishida, Yoshihiro; Shingu, Yuko; Mengfei, Yuan; Fukuda, Kazuo; Dohi, Hirofumi; Matsuda, Sachie; Matsuda, Kazuhiro
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 629 - 639
反应条件
1.1: pyridine; 4-(N,N-dimethlyamino)pyridine / 12 h / 20 °C 2.1: pyridine / 3 h / 20 °C 3.1: trifluoroacetic acid / methanol; dichloromethane / 2 h / 20 °C 4.1: 2-cyanoethyl N,N,N',N'-tetra-isopropylphosphorodiamidite / dichloromethane / 2 h / 20 °C / Inert atmosphere; Molecular sieve 4.2: 1.5 h / 20 °C 4.3: 0.17 h / 0 - 20 °C 5.1: Pearlman's catalist; hydrogen; acetic acid / methanol / 7 h / 20 °C / 760.05 Torr View Scheme
参考文献
Nishida, Yoshihiro; Shingu, Yuko; Mengfei, Yuan; Fukuda, Kazuo; Dohi, Hirofumi; Matsuda, Sachie; Matsuda, Kazuhiro
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 629 - 639
反应条件
1.1: trifluoroacetic acid / methanol; dichloromethane / 2 h / 20 °C 2.1: 2-cyanoethyl N,N,N',N'-tetra-isopropylphosphorodiamidite / dichloromethane / 2 h / 20 °C / Inert atmosphere; Molecular sieve 2.2: 1.5 h / 20 °C 2.3: 0.17 h / 0 - 20 °C 3.1: Pearlman's catalist; hydrogen; acetic acid / methanol / 7 h / 20 °C / 760.05 Torr View Scheme
参考文献
Nishida, Yoshihiro; Shingu, Yuko; Mengfei, Yuan; Fukuda, Kazuo; Dohi, Hirofumi; Matsuda, Sachie; Matsuda, Kazuhiro
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 629 - 639
反应条件
1.1: carbon tetrabromide; triphenylphosphine / N,N-dimethyl-formamide / 3 h / 20 °C 1.2: 14 h / 20 °C 2.1: pyridine; 4-(N,N-dimethlyamino)pyridine / 12 h / 20 °C 3.1: pyridine / 3 h / 20 °C 4.1: trifluoroacetic acid / methanol; dichloromethane / 2 h / 20 °C 5.1: 2-cyanoethyl N,N,N',N'-tetra-isopropylphosphorodiamidite / dichloromethane / 2 h / 20 °C / Inert atmosphere; Molecular sieve 5.2: 1.5 h / 20 °C 5.3: 0.17 h / 0 - 20 °C 6.1: Pearlman's catalist; hydrogen; acetic acid / methanol / 7 h / 20 °C / 760.05 Torr View Scheme
参考文献
Nishida, Yoshihiro; Shingu, Yuko; Mengfei, Yuan; Fukuda, Kazuo; Dohi, Hirofumi; Matsuda, Sachie; Matsuda, Kazuhiro
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 629 - 639
反应条件
1.1: 2-cyanoethyl N,N,N',N'-tetra-isopropylphosphorodiamidite / dichloromethane / 2 h / 20 °C / Inert atmosphere; Molecular sieve 1.2: 1.5 h / 20 °C 1.3: 0.17 h / 0 - 20 °C 2.1: Pearlman's catalist; hydrogen; acetic acid / methanol / 7 h / 20 °C / 760.05 Torr View Scheme
参考文献
Nishida, Yoshihiro; Shingu, Yuko; Mengfei, Yuan; Fukuda, Kazuo; Dohi, Hirofumi; Matsuda, Sachie; Matsuda, Kazuhiro
Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 629 - 639
