2-[[(3R,4S,7S,10S,11R)-3-乙基-11,15-二羟基-3-甲基-10-甲基氨基-6,9-二氧代-7-丙-2-基2-氧杂-5,8-二氮杂双环[10.3.1]十六碳-1(15),12(16),13-三烯-4-羰基]氨基]乙酸合成路线 (共 26 条)
反应条件
1: H2 / Pd/C
2: LiOH / 20 °C
View Scheme
参考文献
Tanaka, Hiroko; Sawayama, Andrew M.; Wandless, Thomas J.
Journal of the American Chemical Society, 2003 , vol. 125, # 23 p. 6864 - 6865
反应条件
1: 90 percent / CuOAc; DBU / toluene
2: 78 percent / PhSH; Cs2CO3 / dimethylformamide
3: 97 percent / EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
4: H2 / Pd
5: EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
6: trifluoroacetic acid; triethylsilane / CH2Cl2
View Scheme
参考文献
Li, Pixu; Evans, Cory D.; Forbeck, Erin M.; Park, Haengsoon; Bai, Ruoli; Hamel, Ernest; Joullie
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4804 - 4807
反应条件
1: 90 percent / CuOAc; DBU / toluene
2: 78 percent / PhSH; Cs2CO3 / dimethylformamide
3: 97 percent / EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
4: H2 / Pd
5: EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
6: trifluoroacetic acid; triethylsilane / CH2Cl2
View Scheme
参考文献
Li, Pixu; Evans, Cory D.; Forbeck, Erin M.; Park, Haengsoon; Bai, Ruoli; Hamel, Ernest; Joullie
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4804 - 4807
反应条件
1: 97 percent / EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
2: H2 / Pd
3: EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
4: trifluoroacetic acid; triethylsilane / CH2Cl2
View Scheme
参考文献
Li, Pixu; Evans, Cory D.; Forbeck, Erin M.; Park, Haengsoon; Bai, Ruoli; Hamel, Ernest; Joullie
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4804 - 4807
反应条件
1: 78 percent / PhSH; Cs2CO3 / dimethylformamide
2: 97 percent / EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
3: H2 / Pd
4: EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
5: trifluoroacetic acid; triethylsilane / CH2Cl2
View Scheme
参考文献
Li, Pixu; Evans, Cory D.; Forbeck, Erin M.; Park, Haengsoon; Bai, Ruoli; Hamel, Ernest; Joullie
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4804 - 4807
反应条件
1: H2 / Pd
2: EDCI*HCl; HOBt; NaHCO3 / dimethylformamide
3: trifluoroacetic acid; triethylsilane / CH2Cl2
View Scheme
参考文献
Li, Pixu; Evans, Cory D.; Forbeck, Erin M.; Park, Haengsoon; Bai, Ruoli; Hamel, Ernest; Joullie
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4804 - 4807