2,2-二氟-1,3-苯并二恶茂合成路线 （共 22 条）
反应条件
1: 88 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / -75 °C 2: 95 percent / sodium borohydride / methanol / 0.25 h / 0 °C View Scheme
参考文献
Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva
European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462
反应条件
bromine; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-75°C; 2 h;
参考文献
Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva
European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462
反应条件
1: 2,2-difluoro-1,3-benzodioxole With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-75°C; 2 h; 2: carbon dioxide in tetrahydrofuran; cyclohexane T=-78°C; Further stages.;
参考文献
Castagnetti, Eva; Schlosser, Manfred
European Journal of Organic Chemistry, 2001 , # 4 p. 691 - 695
反应条件
1: 2,2-difluoro-1,3-benzodioxole With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 1.5 h; 2: boric acid trimethyl ester in tetrahydrofuran; cyclohexane T=-78 - -30°C; 3: With hydrogenchloride; water in tetrahydrofuran; cyclohexane
参考文献
WO2012/76877 A1, ;
Page/Page column 167-168 ;
WO 2012/076877 A1
反应条件
1: With sec.-butyllithium in tetrahydrofuran; cyclohexane T=-78°C; 1.5 h; 2: With boric acid trimethyl ester in tetrahydrofuran; cyclohexane T=-78 - -30°C; 3: With hydrogenchloride; water in tetrahydrofuran; cyclohexane
参考文献
US2013/267510 A1, ;
Paragraph 1074-1076 ;
反应条件
hydrogenchloride; n-butyllithium; sodium chloride in tetrahydrofuran; Petroleum ether
反应条件
1: 88 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / -75 °C 2: 68 percent / iodine; ammonia / tetrahydrofuran; H2O / 2 h / 25 °C View Scheme
参考文献
Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva
European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462
反应条件
sec.-butyllithium in tetrahydrofuran; cyclohexane
T=-75°C;
参考文献
Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva
European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462
反应条件
1: 27 percent / sec-butyllithium / tetrahydrofuran; cyclohexane / 3 h / -75 °C
2: 86 percent / triphenylphosphane; bromine / acetonitrile / 2 h / 50 °C
View Scheme
参考文献
Schlosser, Manfred; Gorecka, Joanna; Castagnetti, Eva
European Journal of Organic Chemistry, 2003 , # 3 p. 452 - 462
反应条件
1.1: secBuLi / tetrahydrofuran; cyclohexane / 2 h / -75 °C
1.2: 92 percent / tetrahydrofuran; cyclohexane / -75 °C
2.1: secBuLi / tetrahydrofuran; cyclohexane / 2 h / -75 °C
2.2: 95 percent / Br2 / tetrahydrofuran; cyclohexane / -75 °C
3.1: 85 percent / (iPr)2NH; BuLi / tetrahydrofuran; hexane / 2 h / -75 °C
View Scheme
参考文献
Gorecka, Joanna; Leroux, Frederick; Schlosser, Manfred
European Journal of Organic Chemistry, 2004 , # 1 p. 64 - 68
