1: 6-bromo-1,3-dihydro-2H-indol-2-one With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C;
3: With sodium hydrogencarbonate in tetrahydrofuran; hexane; water
sodium hydroxide in ethanol
1 h; Ambient temperature;
参考文献
Atwal, Karnail S.; Ferrara, Francis N.; Ding, Charles Z.; Grover, Gary J.; Sleph, Paul G.; Dzwonczyk, Steven; Baird, Anne J.; Normandin, Diane E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 304 - 313
1: 51 percent / N-bromophthalimide / benzene
2: 98 percent / H2SO4 / dioxane
3: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 2 h
4: 98 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Atwal, Karnail S.; Ferrara, Francis N.; Ding, Charles Z.; Grover, Gary J.; Sleph, Paul G.; Dzwonczyk, Steven; Baird, Anne J.; Normandin, Diane E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 304 - 313
1: 98 percent / H2SO4 / dioxane
2: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 2 h
3: 98 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Atwal, Karnail S.; Ferrara, Francis N.; Ding, Charles Z.; Grover, Gary J.; Sleph, Paul G.; Dzwonczyk, Steven; Baird, Anne J.; Normandin, Diane E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 304 - 313
1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 2 h
2: 98 percent / 1 N aq. NaOH / ethanol / 1 h / Ambient temperature
View Scheme
参考文献
Atwal, Karnail S.; Ferrara, Francis N.; Ding, Charles Z.; Grover, Gary J.; Sleph, Paul G.; Dzwonczyk, Steven; Baird, Anne J.; Normandin, Diane E.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 304 - 313
