5-溴-1-氯-2,3-二氢-1H-茚合成路线 (共 2 条)
反应条件
thionyl chloride in dichloromethane T=-10 - 20°C; 14 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/63239 A1, 2005 ;
Location in patent: Page/Page column 137-138 ;
WO 2005/063239 A1
反应条件
1: NaBH4 / methanol 2: SOCl2 / toluene View Scheme
参考文献
Harbin Gloria Pharmaceuticals Co., Ltd.
Patent: EP2385035 A1, 2011 ;