3-(2,2,2-三氟乙酰基)四氢吡喃-4-酮合成路线 （共 2 条）
反应条件
1: tetrahydro-pyran-4-one With lithium diisopropyl amide in tetrahydrofuran T=-70°C; 1 h; 2: ethyl-α,α,α-trifluoroacetate in tetrahydrofuran T=-70 - 20°C; 16 h;
参考文献
GLAXO GROUP LIMITED
Patent: US2010/137276 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With sodium methylate in di-isopropyl ether T=20°C; 20 h; Cooling with ice; 2: With acetic acid
参考文献
La Rosa, Salvatore; Benicchi, Tiziana; Bettinetti, Laura; Ceccarelli, Ilaria; Diodato, Enrica; Federico, Cesare; Fiengo, Pasquale; Franceschini, Davide; Gokce, Ozgun; Heitz, Freddy; Lazzeroni, Giulia; Luthi-Carter, Ruth; Magnoni, Letizia; Miragliotta, Vincenzo; Scali, Carla; Valacchi, Michela
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 979 - 984
