7-甲氧基-1-萘并ni三le合成路线 （共 17 条）
反应条件
1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 - 45 °C / |Inert atmosphere 2: ammonium acetate / toluene / 14 h / 100 °C 3: palladium 10 on activated carbon; acetic acid View Scheme
参考文献
Kandagatla, Bhaskar; Raju, Vetukuri Venkata Naga Kali Vara Prasada; Reddy, Ganta Madhusudhan; Rao, Sirigiri Chandrakanth; Iqbal, Javed; Bandichhor, Rakeshwar; Oruganti, Srinivas
Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7125 - 7127
反应条件
1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 - 45 °C / |Inert atmosphere 2: ammonium acetate / toluene / 14 h / 100 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 20 °C / 3102.97 Torr View Scheme
参考文献
Kandagatla, Bhaskar; Raju, Vetukuri Venkata Naga Kali Vara Prasada; Reddy, Ganta Madhusudhan; Rao, Sirigiri Chandrakanth; Iqbal, Javed; Bandichhor, Rakeshwar; Oruganti, Srinivas
Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7125 - 7127
反应条件
diisobutylaluminium hydride in dichloromethane; toluene T=-78 - 45°C; 2 h; Inert atmosphere;
参考文献
Kandagatla, Bhaskar; Raju, Vetukuri Venkata Naga Kali Vara Prasada; Reddy, Ganta Madhusudhan; Rao, Sirigiri Chandrakanth; Iqbal, Javed; Bandichhor, Rakeshwar; Oruganti, Srinivas
Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7125 - 7127
反应条件
1.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
2.1: Br2; acetic acid / 6 h / 100 °C
2.2: aq. HCl; SnCl2 / 1 h / 100 °C
3.1: 2.41 g / K2CO3 / acetone / Heating
4.1: 13 percent / Selectfluor / acetonitrile / 20 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1: With bromine in acetic acid
T=45°C; Reflux;
2: With hydrogenchloride; SnCl4 in water; acetic acid
T=100°C;
参考文献
Hartmann, Rolf; Frotscher, Martin; Oberwinkler, Sandrine; Ziegler, Erika; Messinger, Josef; Thole, Heinrich-Hubert
Patent: US2010/204234 A1, 2010 ;
Location in patent: Page/Page column 14 ;
US 20100204234 A1
反应条件
1.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
2.1: Br2; acetic acid / 6 h / 100 °C
2.2: aq. HCl; SnCl2 / 1 h / 100 °C
3.1: aq. Na2CO3; Pd[P(Ph)3]4 / 1,2-dimethoxy-ethane / 85 °C
4.1: 0.085 g / C6H5N*HCl / 2 h / 190 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
反应条件
1.1: 0.88 g / C6H5N*HCl / 2 h / 190 °C
2.1: Br2; acetic acid / 6 h / 100 °C
2.2: aq. HCl; SnCl2 / 1 h / 100 °C
View Scheme
参考文献
Mewshaw, Richard E.; Edsall Jr., Richard J.; Yang, Cuijian; Manas, Eric S.; Xu, Zhang B.; Henderson, Ruth A.; Keith Jr., James C.; Harris, Heather A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 3953 - 3979
