1: in dichloromethane Substitution; 4 h; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran; dichloromethane Hydrolysis; 1 h; 3: With alkaline phosphatase T=20°C; Hydrolysis; pH=8; 16 h; Title compound not separated from byproducts;

1.1: 100 percent / pyridine / 1 h / 0 °C 2.1: iodotrimethylsilane / CH2Cl2 / 0.5 h / 20 °C 3.1: CH2Cl2 / 4 h 3.2: tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 1 h 3.3: alkaline phosphatase / various solvent(s) / 16 h / 20 °C / pH 8 View Scheme

1.1: iodotrimethylsilane / CH2Cl2 / 0.5 h / 20 °C 2.1: CH2Cl2 / 4 h 2.2: tetrabutylammonium fluoride / CH2Cl2; tetrahydrofuran / 1 h 2.3: alkaline phosphatase / various solvent(s) / 16 h / 20 °C / pH 8 View Scheme

mit Hilfe eines Enzym-Praeparats von Phaseolus aureus;