2-甲基1-(2-甲基-2-丙基)4,4-二甲基-5-氧代-1,2-吡咯烷二羧酸酯合成路线 （共 7 条）
反应条件
1: N-BOC-L-methyl pyroglutamate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.25 h; 2: methyl iodide T=-78 - 20°C; 2.25 h;
参考文献
WO2012/39717 A1, ;
Page/Page column 151 ;
反应条件
1: N-BOC-L-methyl pyroglutamate; Me-X With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 2: Me-X With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1604 - 1607
反应条件
1: N-BOC-L-methyl pyroglutamate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 2: methyl iodide in tetrahydrofuran T=-78°C;
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: DMAP / triethylamine; CH2Cl2 2.1: LiN(SiMe3)2 / tetrahydrofuran / -78 °C 2.2: tetrahydrofuran / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1.1: SOCl2 / 0 - 20 °C 2.1: DMAP / triethylamine; CH2Cl2 3.1: LiN(SiMe3)2 / tetrahydrofuran / -78 °C 3.2: tetrahydrofuran / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 15 p. 3203 - 3205
反应条件
1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 2: water; lithium hydroxide hydrate / ethanol / 6 h / 0 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; HEWAWASAM, Piyasena
Patent: WO2012/39717 A1, 2012 ;
反应条件
1: Et3LiBH / tetrahydrofuran / 0.5 h / -78 °C 2: Et3SiH, BF3*Et2O / CH2Cl2 / 2 h / -78 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; HEWAWASAM, Piyasena
Patent: WO2012/39717 A1, 2012 ;
Location in patent: Page/Page column 152 ;
