2-氨基-4-(对甲苯基)噻吩-3-羧酸乙酯合成路线 （共 5 条）
反应条件
1: With ammonium acetate; acetic acid in toluene Gewald Aminoheterocycles Synthesis; Dean-StarkReflux; 2: With sulfur; diethylamine in ethanol T=50°C; Gewald Aminoheterocycles Synthesis; 3 h;
参考文献
Titchenell, Paul M.; Hollis Showalter; Pons, Jean-Francois; Barber, Alistair J.; Jin, Yafei; Antonetti, David A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 3034 - 3038
反应条件
hydrogen sulfide in ethanol; ethyl acetate
参考文献
US2003/73733 A1, ;
US 20030073733 A1
反应条件
sulfur; diethylamine in ethanol 0.0333333 h;
参考文献
Kathiravan; Shishoo; Chitre; Mahadik; Jain
Synthetic Communications, 2007 , vol. 37, # 23 p. 4273 - 4279
反应条件
1: 24 h / 160 - 170 °C 2: tetraphosphorus decasulfide View Scheme
参考文献
Golub, Andriy G.; Bdzhola, Volodymyr G.; Briukhovetska, Nadiia V.; Balanda, Anatoliy O.; Kukharenko, Olexander P.; Kotey, Igor M.; Ostrynska, Olga V.; Yarmoluk, Sergiy M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 870 - 876
反应条件
1: 24 h / 160 - 170 °C 2: phosphorus pentachloride; trichlorophosphate 3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / Heating View Scheme
参考文献
Golub, Andriy G.; Bdzhola, Volodymyr G.; Briukhovetska, Nadiia V.; Balanda, Anatoliy O.; Kukharenko, Olexander P.; Kotey, Igor M.; Ostrynska, Olga V.; Yarmoluk, Sergiy M.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 3 p. 870 - 876
