(2S,5R)-5-苯基吡咯烷-2-甲酸合成路线 （共 7 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol P=22501.8 Torr; Ambient temperature;
参考文献
Fournie-Zaluski, Marie-Claude; Coric, Pascale; Thery, Vincent; Gonzalez, Walter; Meudal, Herve; Turcaud, Serge; Michel, Jean-Baptiste; Roques, Bernard P.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 13 p. 2594 - 2608
反应条件
1: 71 percent / tetrahydrofuran / a) -40 deg C, 1 h, b) 0 deg C, 1 h 2: 94 percent / TFA / CH2Cl2 / 2 h / 0 °C 3: 99 percent / H2 / PtO2 / ethanol / 22501.8 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 13 p. 2594 - 2608
反应条件
1: 71 percent / tetrahydrofuran / a) -40 deg C, 1 h, b) 0 deg C, 1 h 2: 94 percent / TFA / CH2Cl2 / 2 h / 0 °C 3: 99 percent / H2 / PtO2 / ethanol / 22501.8 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 13 p. 2594 - 2608
反应条件
1: 94 percent / TFA / CH2Cl2 / 2 h / 0 °C 2: 99 percent / H2 / PtO2 / ethanol / 22501.8 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 13 p. 2594 - 2608
反应条件
1: p-TsOH*H2O / Ambient temperature 2: 1.) CuBr*Me2S, 2.) BF3*OEt2 / 1.) ether, -40 deg C, 45 min, 2.) -78 deg C, 30 min; 15 min; -78 deg C to room temp., 3 h; room temp., 1 h 3: TFA / CH2Cl2 / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5011 - 5015
反应条件
1: 1.) CuBr*Me2S, 2.) BF3*OEt2 / 1.) ether, -40 deg C, 45 min, 2.) -78 deg C, 30 min; 15 min; -78 deg C to room temp., 3 h; room temp., 1 h 2: TFA / CH2Cl2 / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 16 p. 5011 - 5015
反应条件
hydrogenchloride; water; sodium cyanoborohydride in isopropyl alcohol 2 h; Ambient temperature; Yield givenYields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 9 p. 1193 - 1200
