1-甲基-4-苯基-1H-咪唑-5-甲醛合成路线 （共 4 条）
反应条件
manganese(IV) oxide in 1,4-dioxane
T=20 - 80°C; 8 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/13141 A1, 2004 ;
Location in patent: Page 84 ;
WO 2004/013141 A1
反应条件
1: 4-phenyl-1H-imidazole-5-carbaldehyde With caesium carbonate in DMF (N,N-dimethyl-formamide)
0.166667 h;
2: methyl iodide in DMF (N,N-dimethyl-formamide)
16 h;
3: With water in DMF (N,N-dimethyl-formamide)
1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/58776 A1, 2004 ;
Location in patent: Page 47 ;
WO 2004/058776 A1
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in toluene
Heating;
参考文献
Shapiro; Gomez-Lor
Journal of Organic Chemistry, 1994 , vol. 59, # 19 p. 5524 - 5526
反应条件
potassium permanganate; potassium carbonate in water; acetone
24 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2004/13141 A1, 2004 ;
Location in patent: Page 84 ;
WO 2004/013141 A1
