6,8-二氟-1-(甲酰基甲基氨基)-7-(4-甲基-1-哌嗪基)-4-氧代-1,4-二氢喹啉-3-甲酸乙酯合成路线 (共 6 条)
反应条件
triethylamine in 1-methyl-pyrrolidin-2-one T=100°C; 3 h; Product distribution / selectivity;
参考文献
WO2011/61292 A1, ;
Page/Page column 43-44 ;
反应条件
formic acid; sodium carbonate in acetic acid n-butyl ester; water; ethyl acetate
反应条件
in dichloromethane; tert.-butyl-methyl ether; water; toluene
反应条件
in water; 6,7,8-Trifluor-1-(formylmethylamino)-1,4-dihydro-4-oxo-3-chinolincarbonsaeure-ethylester; toluene
参考文献
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO; ZUPET, Rok; ISKRA, Jernej; RUZIC, Milos; PECAVAR, Anica; KOLENC, Ivanka; PUCELJ, Joze; PLAPER, Igor
Patent: WO2011/61292 A1, 2011 ;
Location in patent: Page/Page column 43-44 ;