5-溴-2,2’-联吡啶合成路线 （共 17 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; Negishi reaction; 33 h;
参考文献
Fang, Yuan-Qing; Hanan, Garry S.
Synlett, 2003 , # 6 p. 852 - 854
反应条件
1: With sulfuric acid; water; nitric acid; potassium bromide T=100°C; 24 h; 2: With sodium hydroxide in water pH=7;
参考文献
Zhao, Jian-Feng; Chen, Lin; Sun, Peng-Ju; Hou, Xiao-Ya; Zhao, Xiang-Hua; Li, Wei-Jie; Xie, Ling-Hai; Qian, Yan; Shi, Nai-En; Lai, Wen-Yong; Fan, Qu-Li; Huang, Wei
Tetrahedron, 2011 , vol. 67, # 10 p. 1977 - 1982
反应条件
tetrakis(triphenylphosphine) palladium(0) in xylene T=120°C; Stille coupling reaction; 12 h;
参考文献
Schwab, Peter F.H.; Fleischer, Frank; Michl, Josef
Journal of Organic Chemistry, 2002 , vol. 67, # 2 p. 443 - 449
反应条件
1: 2-bromo-pyridine With tert.-butyl lithium in tetrahydrofuran T=-78°C; Negishi cross-coupling reaction; 2: With zinc(II) chloride in tetrahydrofuran T=-78 - 20°C; Negishi cross-coupling reaction; 3: 2,5-dibromo-pyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=80°C; Negishi cross-coupling reaction;
参考文献
Piehler, Torsten; Luetzen, Arne
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2010 , vol. 65, # 3 p. 329 - 336
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C;
参考文献
Haino, Takeharu; Araki, Hiromi; Yamanaka, Yuko; Fukazawa, Yoshimasa
Tetrahedron Letters, 2001 , vol. 42, # 18 p. 3203 - 3206
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=20°C; 24 h; Inert atmosphere;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron, 2010 , vol. 66, # 17 p. 3135 - 3146
反应条件
1: 2-bromo-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Negishi coupling; 0.833333 h; Inert atmosphere; 2: With zinc(II) chloride in tetrahydrofuran; hexane T=20°C; Negishi coupling; Inert atmosphere; 3: 5-bromo-2-iodopyridine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane Negishi coupling; 18 h; Inert atmosphereReflux;
参考文献
Soliman, Ahmed M.; Fortin, Daniel; Harvey, Pierre D.; Zysman-Colman, Eli
Chemical Communications, 2012 , vol. 48, # 8 p. 1120 - 1122
参考文献
Phosphorus, Sulfur and Silicon and Related Elements, , vol. 109, # 1-4 p. 605 - 608
反应条件
methanol; bromine in acetonitrile 4 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 36, # 23 p. 4077 - 4080
反应条件
1: 2-bromo-pyridine; tributyltin chloride With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: 2,5-dibromo-pyridine With tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C;
参考文献
Tetrahedron Letters, , vol. 44, # 42 p. 7711 - 7714
