3-溴-5-硝基-2-羟基吡啶合成路线 （共 7 条）
反应条件
bromine in water T=20 - 40°C;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2009/21696 A1, 2009 ;
Location in patent: Page/Page column 42 ;
WO 2009/021696 A1
反应条件
quinoline; trichlorophosphate T=120°C; 2 h;
参考文献
Synthesis, , # 6 p. 499 - 501
反应条件
1: 94 percent / POCl3, quinoline / 2 h / 120 °C 2: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C View Scheme
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
反应条件
1: 94 percent / POCl3, quinoline / 2 h / 120 °C 2: 87 percent / Fe, AcOH / H2O / 2 h / below 50 deg C 3: 1) HBF4, NaNO2 / 1)water, 0 deg C, 1 h, 2) 70 deg C, 1 h 4: 98 percent / 2 N KOH / 0.5 h / 5 °C View Scheme
参考文献
Koch; Schnatterer
Synthesis, 1990 , # 6 p. 499 - 501
反应条件
1: phosphoryl chloride; phosphorus (V)-chloride 2: dimethylformamide; potassium fluoride View Scheme
参考文献
Finger; Starr
Journal of the American Chemical Society, 1959 , vol. 81, p. 2674
参考文献
Merck and Co., Inc.
Patent: US5929094 A1, 1999 ;
US 5929094 A
反应条件
phosphorus tribromide; phosphorus oxytribromide T=120°C; 3.5 h; Product distribution / selectivity;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2009/21696 A1, 2009 ;
Location in patent: Page/Page column 42; 45 ;
WO 2009/021696 A1
