5-溴-2-羟基-3-硝基吡啶合成路线 （共 31 条）
反应条件
sulfuric acid; sodium nitrite in water T=0 - 20°C; Inert atmosphere;
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
反应条件
sulfuric acid; water; nitric acid
参考文献
Yakugaku Zasshi, , vol. 79, p. 1129,1132
Chem.Abstr., , p. 3418
反应条件
sulfuric acid; nitric acid T=20°C; Cooling with ice;
参考文献
US2010/204214 A1, ;
Page/Page column 117 ;
参考文献
Journal of the American Chemical Society, , vol. 77, p. 6053
参考文献
Yakugaku Zasshi, , vol. 79, p. 1129,1132
Chem.Abstr., , p. 3418
反应条件
1: silver carbonate / anhydrous methyl chloride / 48 h / 20 °C / Inert atmosphere; Darkness 2: SnCl2·2H2O / ethyl acetate / 4 h / Reflux 3: pyridine / 0 - 20 °C View Scheme
参考文献
Wang, Min; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1569 - 1574
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 2: ethanol; tin(ll) chloride / 1 h / Reflux 3: pyridine / pyridine / 0.67 h / 0 - 20 °C View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238587 A1, 2012 ;
US 20120238587 A1
反应条件
1: bromine; phosphorus (III)-bromide / 100 °C 2: iron-turnings; acetic acid / 100 °C View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1: phosphoryl chloride; phosphorus (V)-chloride / 100 °C 2: iron-turnings; acetic acid 3: sodium nitrite; aqueous hydrochloric acid; copper-powder / Diazotization View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1.1: phosphorus oxytribromide / N,N-dimethyl-formamide; toluene / 16 h / 90 °C 2.1: anhydrous propionitrile / 17 h / 90 °C 3.1: tetrabutyl ammonium fluoride; sulfuric acid / N,N-dimethyl-formamide / 1 h / -40 °C 3.2: -40 °C / pH 3 View Scheme
