5-溴-2-羟基-3-硝基吡啶合成路线 （共 31 条）
反应条件
tin(ll) chloride in ethyl acetate T=50°C; 20 h;
参考文献
US2005/256137 A1, ;
Page/Page column 10 ;
反应条件
1: silver carbonate / anhydrous methyl chloride / 48 h / 20 °C / Inert atmosphere; Darkness 2: SnCl2·2H2O / ethyl acetate / 4 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
反应条件
1: trichlorophosphate / N,N-dimethyl-formamide / 2 h / Reflux 2: ethanol; tin(ll) chloride / 1 h / Reflux View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1.1: POBr3 / toluene / 80 °C 2.1: dimethylformamide / 120 °C 3.1: SnCl2 / methanol / 50 °C 4.1: NOBF4 / CH2Cl2 4.2: toluene / 100 °C 5.1: aq. HCl / 100 °C View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1: With N,N-dimethyl-formamide; trichlorophosphate 3 h; Heating / reflux; 2: With sodium hydrogencarbonate in diethyl ether
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2007/102059 A1, 2007 ;
Location in patent: Page/Page column 45 ;
反应条件
thionyl chloride in toluene
参考文献
Merck and Co., Inc.
Patent: US6162804 A1, 2000 ;
US 6162804 A
反应条件
in chloroform; trichlorophosphate
参考文献
Smith Kline and French Laboratories Limited
Patent: US4537890 A1, 1985 ;
US 4537890 A
反应条件
1: POBr3 / toluene / 80 °C 2: dimethylformamide / 120 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 13 p. 3608 - 3612
反应条件
1: POBr3 / toluene / 80 °C 2: dimethylformamide / 120 °C 3: SnCl2 / methanol / 50 °C View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1: bromine; phosphorus (III)-bromide / 100 °C 2: iron-turnings; acetic acid / 100 °C 3: CuCN / 150 °C View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
