5-溴-2-羟基-3-硝基吡啶合成路线 （共 31 条）
反应条件
1.1: POBr3 / toluene / 80 °C
2.1: dimethylformamide / 120 °C
3.1: SnCl2 / methanol / 50 °C
4.1: NOBF4 / CH2Cl2
4.2: toluene / 100 °C
5.1: aq. HCl / 100 °C
6.1: EDCI; TEA / dimethylformamide
7.1: LiAlH4 / diethyl ether / -78 °C
View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
