2,5-二溴-3-硝基吡啶合成路线 （共 21 条）
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide; toluene T=90°C; 16 h;
参考文献
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; HERTEL, Cornelia; KONKAR, Anish Ashok; KUEHNE, Holger; KUHN, Bernd; MAERKI, Hans P.; WANG, Haiyan
Patent: WO2012/89601 A1, 2012 ;
Location in patent: Page/Page column 53 ;
WO 2012/089601 A1
反应条件
1: With hydrogen bromide in water T=0 - 5°C; 2: With water; bromine; sodium sulfite T=0°C; 0.75 h; 3: With sodium hydroxide in water T=20°C; 1 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1757594 A1, 2007 ;
Location in patent: Page/Page column 76 ;
EP 1757594 A1
反应条件
phosphorus tribromide
反应条件
1: bromine 2: phosphoryl bromide; phosphorus (III)-bromide / 180 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 6053
反应条件
1: 83 percent / sulfuric acid; fuming nitric acid / 3.5 h / 0 - 50 °C 2: hydrobromic acid; bromine; sodium nitrite / H2O View Scheme
参考文献
Tetrahedron, , vol. 59, # 43 p. 8555 - 8570
参考文献
Malinowski, Marek
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 1 p. 51 - 54
参考文献
Hoechst Aktiengesellschaft
Patent: US5445763 A1, 1995 ;
反应条件
1: tin; aqueous HCl 2: sodium nitrite; aqueous hydrochloric acid; copper-powder / Diazotization View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1.1: anhydrous propionitrile / 17 h / 90 °C 2.1: tetrabutyl ammonium fluoride; sulfuric acid / N,N-dimethyl-formamide / 1 h / -40 °C 2.2: -40 °C / pH 3 View Scheme
反应条件
hydrogenchloride; tin
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
