2,5-二溴-3-硝基吡啶合成路线 （共 21 条）
反应条件
1.1: dimethylformamide / 120 °C 2.1: SnCl2 / methanol / 50 °C 3.1: NOBF4 / CH2Cl2 3.2: toluene / 100 °C 4.1: aq. HCl / 100 °C View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
in anhydrous propionitrile T=90°C; 17 h;
参考文献
US2012/165338 A1, ;
Page/Page column 22 ;
参考文献
EP1757594 A1, ;
Page/Page column 76 ;
EP 1757594 A1
反应条件
in anhydrous propionitrile T=90°C; 17 h;
参考文献
WO2005/63690 A1, ;
Page/Page column 29 ;
WO 2005/063690 A1
参考文献
Journal of the Chemical Society, , p. 2042,2044
反应条件
1: dimethylformamide / 120 °C 2: SnCl2 / methanol / 50 °C View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1: iron-turnings; acetic acid / 100 °C 2: CuCN / 150 °C View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
1.1: dimethylformamide / 120 °C
2.1: SnCl2 / methanol / 50 °C
3.1: NOBF4 / CH2Cl2
3.2: toluene / 100 °C
View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1.1: dimethylformamide / 120 °C
2.1: SnCl2 / methanol / 50 °C
3.1: NOBF4 / CH2Cl2
3.2: toluene / 100 °C
4.1: aq. HCl / 100 °C
5.1: EDCI; TEA / dimethylformamide
View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
反应条件
1.1: dimethylformamide / 120 °C
2.1: SnCl2 / methanol / 50 °C
3.1: NOBF4 / CH2Cl2
3.2: toluene / 100 °C
4.1: aq. HCl / 100 °C
5.1: EDCI; TEA / dimethylformamide
6.1: LiAlH4 / diethyl ether / -78 °C
View Scheme
参考文献
Kuduk, Scott D.; DiPardo, Robert M.; Chang, Ronald K.; Di Marco, Christina N.; Murphy, Kathy L.; Ransom, Richard W.; Reiss, Duane R.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3608 - 3612
