6-溴螺[茚-1,4-哌啶]-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=0°C;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2009/67202 A1, 2009 ;
Location in patent: Page/Page column 196 ;
WO 2009/067202 A1
反应条件
lithium hexamethyldisilazane 1.) THF, 4 deg C, 45 min, 2.) THf, from 4 deg C, 2h to RT, 18 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Efange; Khare; Foulon; Akella; Parsons
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2574 - 2582
