2-氨基-6-溴苯并噻唑合成路线 （共 37 条）
反应条件
(i) NaNO2, aq. H2SO4, Py, (ii) /BRN= 742134/, Na2CO3, EtOH; Multistep reaction;
参考文献
Drapkina,D.A. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 1535 - 1540,1522 - 1525
反应条件
triethylamine in tetrahydrofuran T=20°C; 1 h;
参考文献
Chen, Qianqian; Tian, Wei; Han, Guangqian; Qi, Jingjing; Zheng, Canhui; Zhou, Youjun; Ding, Lili; Zhao, Juntao; Zhu, Ju; Lv, Jiaguo; Sheng, Chunquan
European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 176 - 182
参考文献
Journal of the Indian Chemical Society, , vol. 11, p. 249,254
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 2 h;
参考文献
AMGEN INC.
Patent: WO2009/17822 A2, 2009 ;
Location in patent: Page/Page column 50; 67; 68 ;
WO 2009/017822 A2
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=100°C; 12 h;
参考文献
MERCK SERONO S.A.; SWINNEN, Dominique; JORAND-LEBRUN, Catherine; GRIPPI-VALLOTTON, Tania; GERBER, Patrick; GONZALEZ, Jerome; SHAW, Jeffrey; JEYAPRAKASHNARAYANAN, Seenisamy
Patent: WO2010/100144 A1, 2010 ;
Location in patent: Page/Page column 159 ;
WO 2010/100144 A1
反应条件
sodium hydrogencarbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane; water
T=130°C; Suzuki Coupling; 0.5 h; Microwave irradiation;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; DONG, Qing; GONG, Xianchang; HIROSE, Masaaki; JIN, Bohan; ZHOU, Feng
Patent: WO2010/8847 A2, 2010 ;
Location in patent: Page/Page column 128 ;
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium carbonate in 1,4-dioxane; water
T=120°C; Suzuki Coupling; 1.5 h; Microwave irradiationInert atmosphere;
参考文献
Hong, Seunghee; Kim, Jinhee; Yun, Sun-Mi; Lee, Hyunseung; Park, Yoonsu; Hong, Soon-Sun; Hong, Sungwoo
Journal of Medicinal Chemistry, 2013 , vol. 56, # 9 p. 3531 - 3545
反应条件
in ethanol
15 h; Heating;
参考文献
Lin; Kasina
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 4 p. 759 - 761
参考文献
Hunter et al.
Journal of the Chemical Society, 1959 , p. 784,787
参考文献
Hunter; Jones
Journal of the Chemical Society, 1930 , p. 2190,2209
