potassium hydroxide in dimethyl sulfoxide 2 h; Ambient temperature;

nickel-copper T=180 - 237°C; P=29420.3 Torr; Hydrogenation.Anfangsdruck;

1: 86 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / Ambient temperature 2: 51 percent / iodine / methanol / 3 h / Heating; further reagent, further solvent 3: 93 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 2 h / Ambient temperature 4: 88 percent / lithium aluminum hydride / tetrahydrofuran / 4 h / Heating 5: 79 percent / aq. 48percent hydrobromic acid / 2 h / Heating View Scheme