7,7,9,9-四甲基-1,3,8-三氮杂螺[4.5]-2,4-癸二酮合成路线 (共 5 条)
反应条件
in ethanol; water T=85°C; 12 h;
参考文献
AUBURN UNIVERSITY
Patent: WO2005/58814 A2, 2005 ;
Location in patent: Page/Page column 23 ;
参考文献
NOVABAY PHARMACEUTICALS, INC.; JAIN, Rakesh, K.; LOW, Eddy; FRANCAVILLA, Charles; SHIAU, Timothy P.; KIM, Bum; NAIR, Satheesh, K.
Patent: WO2010/54009 A1, 2010 ;
Location in patent: Page/Page column 61 ;
WO 2010/054009 A1
参考文献
Mailey; Day
Journal of Organic Chemistry, 1957 , vol. 22, p. 1061,1065
反应条件
potassium hydroxide; tetrabutyl ammonium fluoride in water; dimethyl sulfoxide; xylene
5 h; Heating / reflux; Product distribution / selectivity;
参考文献
CIBA HOLDING INC.
Patent: WO2008/98877 A1, 2008 ;
Location in patent: Page/Page column 11 ;
反应条件
sodium hydroxide; tetrabutyl ammonium fluoride in water; dimethyl sulfoxide; xylene
6 h; Heating / reflux; Product distribution / selectivity;
参考文献
CIBA HOLDING INC.
Patent: WO2008/98877 A1, 2008 ;
Location in patent: Page/Page column 11 ;