2-甲氧基-5-氰基吡啶合成路线 （共 15 条）
反应条件
1: With water; sodium hydroxide in methanol T=100°C; 2: With hydrogenchloride in water
参考文献
ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel
Patent: WO2010/43377 A1, 2010 ;
Location in patent: Page/Page column 52 ;
WO 2010/043377 A1
反应条件
ammonia; nickel Hydrogenation;
参考文献
YAMANOUCHI PHARMACEUTICAL CO. LTD.
Patent: EP1122242 A1, 2001 ;
反应条件
1: pyridine / dichloromethane / 20 h / 20 °C
2: dimethylsulfoxide-d6 / 25 °C
View Scheme
参考文献
Topczewski, Joseph J.; Quinn, Daniel M.
Organic Letters, 2013 , vol. 15, # 5 p. 1084 - 1087
反应条件
bromine; sodium acetate in acetic acid
T=80°C; 48 h;
参考文献
N.V. Organon; Pharmacopeia Drug Discovery Inc.
Patent: US2007/149577 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: methyllithium With cerium(III) chloride in tetrahydrofuran; hexanes
T=-50°C; 0.5 h; Inert atmosphere;
2: 6-methoxy-3-pyridinecarbonitrile in tetrahydrofuran; hexanes
T=20°C; Inert atmosphere;
3: With ammonium hydroxide in tetrahydrofuran; hexanes
T=-40°C; Inert atmosphere;
参考文献
ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; THORESEN, Lars; JUNG, Jae-Kyu; STRAH-PLEYNET, Sonja; ZHU, Xiuwen; XIONG, Yifeng; YUE, Dawei
Patent: WO2011/25541 A1, 2011 ;
Location in patent: Page/Page column 197 ;
WO 2011/025541 A1
