N-(2’,6’-二甲苯基 )-2-哌啶甲酰胺合成路线 （共 13 条）
反应条件
hydrogen; nickel; acetic acid in methanol T=50°C; P=13446.2 Torr; Product distribution / selectivity;
参考文献
PHARMATHEN S.A.
Patent: WO2009/89842 A1, 2009 ;
Location in patent: Page/Page column 5-6 ;
反应条件
Shvo catalyst in anhydrous butyl ether T=140°C; 1 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 343 - 352
反应条件
1: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, 0 deg C to 5 deg C, 2) THF, r.t. 2: HCl / CH2Cl2 / 0 - 5 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 1 p. 23 - 31
反应条件
1: 74 percent / Et3N / H2O; acetone 2: 1) N-methylmorpholine, isobutyl chloroformate / 1) THF, 0 deg C to 5 deg C, 2) THF, r.t. 3: HCl / CH2Cl2 / 0 - 5 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 1 p. 23 - 31
反应条件
Shvo catalyst in anhydrous butyl ether T=140°C; 2 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 343 - 352
反应条件
1: sodium carbonate / 1 h / 20 °C 2: sodium hydroxide / water / 36 h / |Reflux View Scheme
反应条件
1: triethylamine; dioxane / anschliessend Behandeln mit 2,6-Dimethyl-anilin 2: platinum; aq.-ethanolic HCl / Hydrogenation View Scheme
参考文献
Helvetica Chimica Acta, , vol. 42, p. 1324,1326
反应条件
1: CHCl3; NOCl 2: zinc; formic acid 3: ethanolic sodium ethylate / Erwaermen des Reaktionsprodukts mit wss. HCl View Scheme
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 11, p. 1183,1184
反应条件
1: zinc; formic acid 2: ethanolic sodium ethylate / Erwaermen des Reaktionsprodukts mit wss. HCl View Scheme
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 11, p. 1183,1184
反应条件
2: CHCl3; NOCl 3: zinc; formic acid 4: ethanolic sodium ethylate / Erwaermen des Reaktionsprodukts mit wss. HCl View Scheme
参考文献
Acta Chemica Scandinavica (1947-1973), , vol. 11, p. 1183,1184
