Boc-L-β-高丙氨酸合成路线 （共 20 条）
反应条件
sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide in water; acetonitrile T=0°C; 1 h; Inert atmosphere;
参考文献
Sugimoto, Kenji; Kobayashi, Yuta; Hori, Ayana; Kondo, Takashi; Toyooka, Naoki; Nemoto, Hideo; Matsuya, Yuji
Tetrahedron, 2011 , vol. 67, # 40 p. 7681 - 7685
反应条件
silver benzoate in 1,4-dioxane; water T=70°C; Wolff rearrangement; 5 h;
参考文献
Patil, Basanagoud S.; Vasanthakumar, Ganga-Ramu; Suresh Babu
Synthetic Communications, 2003 , vol. 33, # 18 p. 3089 - 3096
反应条件
sodium hydroxide in methanol T=20°C; Hydrolysis; 18 h;
参考文献
Yang, Hua; Jurkauskas, Valdas; Mackintosh, Nicole; Mogren, Tobias; Stephenson, Corey R. J.; Foster, Katherine; Brown, William; Roberts, Edward
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 800 - 808
反应条件
1: Et3N / dioxane 2: KOCl / dioxane; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1274 - 1279
反应条件
dipyridinium dichromate in N,N-dimethyl-formamide
参考文献
Alcon, Montserrat; Canas, Marc; Poch, Marta; Moyano, Albert; Pericas, Miquel A.; Riera, Antoni
Tetrahedron Letters, 1994 , vol. 35, # 10 p. 1589 - 1592
反应条件
1: 93 percent / 1H-benzotriazol-1-yl-N-oxytrispyrrolidinophosphonium PF6(1-); N-ethyldiisopropylamine / tetrahydrofuran; dimethylformamide; diethyl ether / 0.25 h / 0 °C 2: 88 percent / silver benzoate / dioxane; H2O / 70 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 42, # 7 p. 1691 - 1695
反应条件
potassium hydroxide in ethanol; water T=90°C; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., , vol. 126, # 14 p. 3668 - 3672,5
反应条件
1: diethyl ether; tetrahydrofuran / 18 h / 20 °C 2: 96 percent / silver benzoate; Et3N / 18 h / 20 °C 3: 100 percent / 10 percent aq. NaOH / methanol / 18 h / 20 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 78, # 6 p. 800 - 808
反应条件
1: N-tert-butoxycarbonyl-L-alanine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=-15°C; Arndt-Eistert Homologation; 1 h; 2: diazomethane in tetrahydrofuran Arndt-Eistert Homologation; 3: With silver benzoate; silica gel in ethyl acetate T=50°C; Arndt-Eistert Homologation; 0.5 h;
参考文献
Journal of Peptide Science, , vol. 18, # 9 p. 556 - 559
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 24 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 5 p. 1421 - 1425
