2,4-二羟基-7-甲氧基-2H-1,4-苯并噁嗪-3(4H)-酮合成路线 （共 18 条）
反应条件
diisobutylaluminium hydride in toluene T=-78 - 0°C; 2 h;
参考文献
Sicker; Hartenstein
Synthesis, 1993 , # 8 p. 771 - 772
反应条件
1: With boron trichloride in dichloromethane T=20°C; 2.5 h; 2: With silver carbonate in tetrahydrofuran; water 0.333333 h;
参考文献
Handler, Norbert; Erker, Thomas
Scientia Pharmaceutica, 2005 , vol. 73, # 3 p. 95 - 100
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=25°C; 2 h;
参考文献
Hartenstein, Holger; Sicker, Dieter
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4335 - 4338
反应条件
1: NaBH4 / Pt-C / methanol; H2O / 1 h / 25 °C 2: LDA / toluene; hexane / 3 h / -70 °C 3: MCPBA / CH2Cl2 / 2 h / -5 °C 4: Bu4NF*3H2O / tetrahydrofuran / 2 h / 25 °C View Scheme
参考文献
Hartenstein, Holger; Sicker, Dieter
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4335 - 4338
反应条件
1: NaBH4 / Pd/C / H2O; dioxane / 2.5 h 2: 90 percent / BCl3 / CH2Cl2 / 1 h / -40 - -5 °C View Scheme
参考文献
Tays, Kevin; Atkinson, Jeffrey
Synthetic Communications, 1998 , vol. 28, # 5 p. 903 - 912
反应条件
1.1: 53.8 percent / NaBH4 / palladium on charcoal / dioxane; H2O / 0.5 h / 15 - 20 °C 2.1: BCl3 / CH2Cl2 / 2.5 h / 20 °C 2.2: 30 percent / Ag2CO3 / H2O; tetrahydrofuran / 0.33 h View Scheme
参考文献
Handler, Norbert; Erker, Thomas
Scientia Pharmaceutica, 2005 , vol. 73, # 3 p. 95 - 100
反应条件
1.1: 66 percent / 2 h / 20 °C 2.1: 53.8 percent / NaBH4 / palladium on charcoal / dioxane; H2O / 0.5 h / 15 - 20 °C 3.1: BCl3 / CH2Cl2 / 2.5 h / 20 °C 3.2: 30 percent / Ag2CO3 / H2O; tetrahydrofuran / 0.33 h View Scheme
参考文献
Handler, Norbert; Erker, Thomas
Scientia Pharmaceutica, 2005 , vol. 73, # 3 p. 95 - 100
反应条件
1: LDA / toluene; hexane / 3 h / -70 °C 2: MCPBA / CH2Cl2 / 2 h / -5 °C 3: Bu4NF*3H2O / tetrahydrofuran / 2 h / 25 °C View Scheme
参考文献
Hartenstein, Holger; Sicker, Dieter
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4335 - 4338
反应条件
T=37°C; 4 h; β-glucosidase, HOAc-NaOAc buffer (pH 5.1);
参考文献
Nakagawa, Eri; Amano, Takashi; Hirai, Nobuhiro; Iwamura, Hajime
Phytochemistry (Elsevier), 1995 , vol. 38, # 6 p. 1349 - 1354
反应条件
Mythimna separata midgut tissue in CHES buffer; water; dimethyl sulfoxide T=30°C; 1.5 h; Enzymatic reaction;
参考文献
Sasai, Hiroaki; Ishida, Masahiro; Murakami, Kenjiro; Tadokoro, Naoko; Ishihara, Atsushi; Nishida, Ritsuo; Mori, Naoki
Bioscience, Biotechnology and Biochemistry, 2009 , vol. 73, # 6 p. 1333 - 1338
