4''-(戊氧基)-[1,1':4',1''-三联苯]-4-甲酸甲酯合成路线 （共 3 条）
反应条件
1: 2 N aq. NaOH / dioxane / 17 h / Heating 2: dicyclohexylcarbodiimide / CH2Cl2 / Ambient temperature View Scheme
参考文献
Debono, Manuel; Turner, William W.; LaGrandeur, Lisa; Burkhadt, Fred J.; Nissen , Jeffrey S.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3271 - 3281
反应条件
1: With N-hexadecyl-N,N,N-trimethylammonium bromide; potassium hydroxide in anhydrous xylene 3 h; Reflux; 2: With hydrogenchloride; water in ethylene glycol dimethyl ether pH=1; 0.5 h; Reflux;
参考文献
Yao, Jianzhong; Liu, Hongming; Zhou, Ting; Chen, Hai; Miao, Zhenyuan; Sheng, Chunquan; Zhang, Wannian
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 196 - 208
反应条件
1: 2 N aq. NaOH / dioxane / 17 h / Heating 2: dicyclohexylcarbodiimide / CH2Cl2 / Ambient temperature 3: dimethylformamide / Ambient temperature View Scheme
参考文献
Debono, Manuel; Turner, William W.; LaGrandeur, Lisa; Burkhadt, Fred J.; Nissen , Jeffrey S.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3271 - 3281
