5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-羧酸乙酯合成路线 （共 30 条）
反应条件
trimethylaluminum in tetrahydrofuran; toluene T=125°C; 0.0333333 h;
参考文献
Gustafsson, Tomas; Ponten, Fritiof; Seeberger, Peter H.
Chemical Communications, 2008 , # 9 p. 1100 - 1102
反应条件
triethylamine; magnesium chloride in acetonitrile 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
ZENTIVA, A.S.
Patent: WO2008/64615 A2, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
triethylamine; magnesium chloride in acetonitrile 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
ZENTIVA, A.S.
Patent: WO2008/64615 A2, 2008 ;
Location in patent: Page/Page column 14-15 ;
反应条件
magnesium chloride in tetrahydrofuran T=80°C; 2 - 4 h; Product distribution / selectivity;
参考文献
ZENTIVA, A.S.
Patent: WO2008/64615 A2, 2008 ;
Location in patent: Page/Page column 15-16 ;
反应条件
1: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis 2: DMF / CH2Cl2 / 3 h / 20 °C 3: 66 percent / triethylamine / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Hernandez-Vazquez, Eduardo; Aguayo-Ortiz, Rodrigo; Ramirez-Espinosa, Juan Jose; Estrada-Soto, Samuel; Hernandez-Luis, Francisco
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 10 - 21
反应条件
sodium hydroxide in 1,4-dioxane T=70°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1151 - 1154
参考文献
US2007/213302 A1, ;
Page/Page column 11; 12; 27 ;
US 20070213302 A1
反应条件
magnesium chloride in tetrahydrofuran T=80°C; 2 - 4 h; Product distribution / selectivity;
参考文献
WO2008/64615 A2, ;
Page/Page column 15-16 ;
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene
T=65°C; 6 h;
参考文献
SANOFI-AVENTIS
Patent: US2007/99978 A1, 2007 ;
Location in patent: Page/Page column 7 ;
US 20070099978 A1
反应条件
pyridine; copper diacetate in dichloromethane
T=20°C; 48 h; 4 Å molecular sievesUnder air;
参考文献
Sandoz AG
Patent: WO2008/101860 A1, 2008 ;
Location in patent: Page/Page column 7-8 ;
