5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-羧酸乙酯合成路线 （共 30 条）
反应条件
1: 65 percent / LDA; potassium t-butoxide / diethyl ether; tetrahydrofuran; heptane / 2.5 h / 20 °C
2: HCl / H2O; CH2Cl2
3: ethanol / Heating
View Scheme
参考文献
Seltzman, Herbert H.; Carroll, F. Ivy; Burgess, Jason P.; Wyrick, Christopher D.; Burch, David F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 1 p. 59 - 70
反应条件
in methanol
T=-10 - -5°C; 5 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/62480 A2, 2008 ;
Location in patent: Page/Page column 14-15 ;
反应条件
in ethanol
T=20°C; 48 h;
参考文献
Moloney, Gerard P.; Angus, James A.; Robertson, Alan D.; Stoermer, Martin J.; Robinson, Michael; Lay, Lucy; Wright, Christine E.; McRae, Ken; Christopoulos, Arthur
Australian Journal of Chemistry, 2008 , vol. 61, # 7 p. 484 - 499
反应条件
1: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating
2: sodium / ethanol / 2.5 h / 0 °C
View Scheme
参考文献
Dutta, Aloke K.; Sard, Howard; Ryan, William; Razdan, Raj K.; Compton, David R.; Martin, Billy R.
Medicinal Chemistry Research, 1995 , vol. 5, # 1 p. 54 - 62
反应条件
1: 24 percent HCl; NaNO2 / H2O / 0 - 5 °C
2: sodium / ethanol / 2.5 h / 0 °C
View Scheme
参考文献
Dutta, Aloke K.; Sard, Howard; Ryan, William; Razdan, Raj K.; Compton, David R.; Martin, Billy R.
Medicinal Chemistry Research, 1995 , vol. 5, # 1 p. 54 - 62
反应条件
1: triethylamine / ethanol / 20 h / 20 °C
2: acetic acid / 24 h / Reflux
View Scheme
参考文献
Tu, Guogang; Xiong, Fang; Huang, Huiming; Kuang, Binhai; Li, Shaohua
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 2 p. 222 - 230
反应条件
1: triethylamine / ethanol / 20 h / 20 °C
2: acetic acid / 24 h / Reflux
View Scheme
参考文献
Tu, Guogang; Xiong, Fang; Huang, Huiming; Kuang, Binhai; Li, Shaohua
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 2 p. 222 - 230
反应条件
1: lithium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / |Inert atmosphere
2: acetic acid / 12 h / |Reflux
View Scheme
参考文献
Jiang, Jian-An; Huang, Wei-Bin; Zhai, Jiao-Jiao; Liu, Hong-Wei; Cai, Qi; Xu, Liu-Xin; Wang, Wei; Ji, Ya-Fei
Tetrahedron, 2013 , vol. 69, # 2 p. 627 - 635
反应条件
in ethanol
Heating; Yield given. Yields of byproduct given;
参考文献
Seltzman, Herbert H.; Carroll, F. Ivy; Burgess, Jason P.; Wyrick, Christopher D.; Burch, David F.
Journal of the Chemical Society, Chemical Communications, 1995 , # 15 p. 1549 - 1550
参考文献
Alvarado, Mario; Goya, Pilar; Macias-Gonzalez, Manuel; Pavon, Francisco Javier; Serrano, Antonia; Jagerovic, Nadine; Elguero, Jose; Gutierrez-Rodriguez, Angel; Garcia-Granda, Santiago; Suardiaz, Margarita; Rodriguez de Fonseca, Fernando
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 23 p. 10098 - 10105
