6-三氟甲基磺酰基氧基-1,2,3,4-四氢-异喹啉-2-羧酸叔丁酯合成路线 （共 13 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C; 0.75 h; Yield given;
参考文献
Synthetic Communications, , vol. 25, # 20 p. 3255 - 3261
反应条件
1: 65 percent / Et3N; Pd(OAc)2; 1,3-bis(diphenylphosphino)propane / 70 °C 2: 99 percent / aq. NaOH / methanol; tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Haginoya, Noriyasu; Kobayashi, Syozo; Komoriya, Satoshi; Yoshino, Toshiharu; Suzuki, Makoto; Shimada, Takashi; Watanabe, Kengo; Hirokawa, Yumiko; Furugori, Taketoshi; Nagahara, Takayasu
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5167 - 5182
反应条件
1: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate in N,N-dimethyl-formamide
T=80°C; 7 h;
2: With water
参考文献
NEUROGEN CORPORATION
Patent: WO2007/106349 A2, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/106349 A2
