4-(Boc-哌嗪-1-基)-苯甲酸甲酯合成路线 （共 8 条）
反应条件
1: piperazine-1-carboxylic acid tert-butyl ester With rac-2, 2'-bis(diphenylphosphine)-1,1'-binaphthyl; sodium t-butanolate; palladium diacetate in tetrahydrofuran T=20°C; 0.5 h; 2: 4-Bromo-benzoic acid methyl ester With hydrogenchloride in tetrahydrofuran T=70°C; 14 h;
参考文献
WO2003/105853 A1, ;
Page 41 ;
WO 03/105853 A1
反应条件
carbon monoxide; triethylamine in N-methyl-acetamide; methanol; dichloromethane
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
WO2006/38039 A1, ;
Page/Page column 15 ;
反应条件
1: potassium carbonate / butan-1-ol / 177 h / |Reflux 2: 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661
反应条件
sodium hydroxide; diisobutylaluminium hydride in tetrahydrofuran; water; toluene
参考文献
Merck Sharpe and Dohme Ltd.
Patent: US5432177 A1, 1995 ;
反应条件
in various solvent(s) T=150°C; 5 h; microwave irradiation;
参考文献
F. Hoffmann-La Roche AG
Patent: EP2070899 A1, 2009 ;
Location in patent: Page/Page column 7-8 ;
反应条件
sodium hydroxide in ethanol; water T=60°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/148840 A1, 2008 ;
Location in patent: Page/Page column 66 ;
WO 2008/148840 A1
