(S)-1-苄基-吡咯烷-3-甲腈合成路线 （共 9 条）
参考文献
Warner-Lambert Company
Patent: US5347017 A1, 1994 ;
反应条件
n-Bu4N+CN- in dimethyl sulfoxide T=60 - 65°C; 60 h;
参考文献
Thomas, Christoph; Orecher, Florian; Gmeiner, Peter
Synthesis, 1998 , # 10 p. 1491 - 1496
反应条件
in N,N-dimethyl-formamide T=60°C; 48 h;
参考文献
Gmeiner, Peter; Orecher, Florian; Thomas, Christoph; Weber, Klaus
Tetrahedron Letters, 1995 , vol. 36, # 3 p. 381 - 382
反应条件
1: Et3N / tetrahydrofuran / 1.5 h / -25 °C 2: H2 / 20percent Pd(OH)2/C / ethanol / 0.33 h / 757.6 Torr 3: 93 percent / Bu4NCN / dimethylsulfoxide / 60 h / 60 - 65 °C View Scheme
参考文献
Thomas, Christoph; Orecher, Florian; Gmeiner, Peter
Synthesis, 1998 , # 10 p. 1491 - 1496
反应条件
1: 97 percent / LiAlH4 / tetrahydrofuran / 1.) 0 deg C, 14 h, 2.) room temp., 1 h 2: Et3N / tetrahydrofuran / 1.5 h / -25 °C 3: H2 / 20percent Pd(OH)2/C / ethanol / 0.33 h / 757.6 Torr 4: 93 percent / Bu4NCN / dimethylsulfoxide / 60 h / 60 - 65 °C View Scheme
参考文献
Thomas, Christoph; Orecher, Florian; Gmeiner, Peter
Synthesis, 1998 , # 10 p. 1491 - 1496
反应条件
1: Et3N 2: 61 percent / dimethylformamide / 48 h / 60 °C View Scheme
参考文献
Fedij, Victor; Lenoir, Edward A.; Suto, Mark J.; Zeller, James R.; Wemple, James
Tetrahedron: Asymmetry, 1994 , vol. 5, # 7 p. 1131 - 1134
反应条件
1: NaCNBH3 2: Et3N 3: 61 percent / dimethylformamide / 48 h / 60 °C View Scheme
参考文献
Gmeiner, Peter; Orecher, Florian; Thomas, Christoph; Weber, Klaus
Tetrahedron Letters, 1995 , vol. 36, # 3 p. 381 - 382
反应条件
1: HCl, H2O / 0.5 h / Heating 2: SOCl2 / 1.) -50 deg C to room temp., 3 h, 2.) room temp., 11 h 3: 73 percent / H2 / 20percent Pd(OH)2/C / methanol / 16 h / 759.8 Torr / Ambient temperature View Scheme
参考文献
Thomas, Christoph; Orecher, Florian; Gmeiner, Peter
Synthesis, 1998 , # 10 p. 1491 - 1496
反应条件
hydrogenchloride; water T=80°C; 4 h;
参考文献
Gmeiner, Peter; Orecher, Florian; Thomas, Christoph; Weber, Klaus
Tetrahedron Letters, 1995 , vol. 36, # 3 p. 381 - 382
