4-乙酰基-5-甲基异恶唑-3-甲酸乙酯合成路线 (共 11 条)
反应条件
1: 2-amino-2-methyl-propan-1-ol With n-butyllithium in dichloromethane T=0°C; Metallation; after the reagent addition stirring for 15 min at this temperature under nitrogen, then warming to reflux; 2: ethyl 4-acetyl-5-methyl-1,2-oxazole-3-carboxylate Hydrolysis; 12 h; reflux;
参考文献
Zhou, Peiwen; Natale
Synthetic Communications, 1998 , vol. 28, # 18 p. 3317 - 3330