1,2,3,4-四氢异喹啉-3-羧酸乙酯合成路线 （共 11 条）
反应条件
hydrogenchloride 18 h; Heating / reflux;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/72086 A2, 2004 ;
Location in patent: Page 181 ;
参考文献
Sanchez, Remedios; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Solis, Aida
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1399 - 1401
反应条件
1: palladium / 170 °C / 25 Torr 2: potassium ethylate; toluene / und anschliessend mit wss. Salzsaeure View Scheme
参考文献
Clemo; Popli
Journal of the Chemical Society, 1951 , p. 1406,1408
反应条件
palladium T=170°C; P=25 Torr;
参考文献
Clemo; Popli
Journal of the Chemical Society, 1951 , p. 1406,1408
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kang, Chuanqing; Bian, Zheng; He, Yabing; Han, Fushe; Qiu, Xuepeng; Gao, Lianxun
Chemical Communications, 2011 , vol. 47, # 38 p. 10746 - 10748
反应条件
chicken liver acetone; water pH=7.5;
参考文献
Sanchez, Remedios; Luna, Hector; Perez, Herminia I.; Manjarrez, Norberto; Solis, Aida
Tetrahedron Asymmetry, 2001 , vol. 12, # 10 p. 1399 - 1401
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kang, Chuanqing; Bian, Zheng; He, Yabing; Han, Fushe; Qiu, Xuepeng; Gao, Lianxun
Chemical Communications, 2011 , vol. 47, # 38 p. 10746 - 10748
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kang, Chuanqing; Bian, Zheng; He, Yabing; Han, Fushe; Qiu, Xuepeng; Gao, Lianxun
Chemical Communications, 2011 , vol. 47, # 38 p. 10746 - 10748
反应条件
1: tetrahydrofuran / 1.) -20 deg C, 10 min, 2.) RT, 1 h
2: HCl / ethyl acetate / 3 h
3: Et3N / CH2Cl2 / 4 h
4: H2 / Pd black / ethanol; acetic acid / 30 h / Ambient temperature
5: 1 N aq. NaOH / ethanol / 30 h / Ambient temperature
View Scheme
参考文献
Kikumoto; Tamao; Ohkubo; Tezuka; Tonomura; Okamoto; Hijikata
Journal of medicinal chemistry, 1980 , vol. 23, # 12 p. 1293 - 1299
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kang, Chuanqing; Bian, Zheng; He, Yabing; Han, Fushe; Qiu, Xuepeng; Gao, Lianxun
Chemical Communications, 2011 , vol. 47, # 38 p. 10746 - 10748
