(S)-(-)-1-萘基-1-乙醇合成路线 （共 81 条）
反应条件
sodium hydrogencarbonate; sodium bromide; chiral azabicyclo-N-oxyl in dichloromethane T=0°C; Electrochemical reaction;
参考文献
Shiigi, Hirofumi; Mori, Hiroyuki; Tanaka, Tomoaki; Demizu, Yosuke; Onomura, Osamu
Tetrahedron Letters, 2008 , vol. 49, # 36 p. 5247 - 5251
反应条件
chiral 2-(3',5'-di-tert-butylphenyl)-4,4,8-trimethyl-2-phosphabicyclolt;3.3.0gt;octane in toluene T=-40°C; 7 h;
参考文献
Journal of the American Chemical Society, , vol. 121, # 24 p. 5813 - 5814
反应条件
Candida antarctica lipase B in 1,1,1,2-tetrafluoroethane T=25°C; 72 h; Resolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Ball, Anthony J.; Corr, Stuart; Micklefield, Jason
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3543 - 3546
反应条件
1: With N,N-bis(3,5-di-t-butylbenzyl)-O-benzyl-L-α-aspartyl-L-proline methyl ester in toluene T=0 - 20°C; 48 h; Inert atmosphere; 2: With hydrogenchloride in water; toluene Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Kang, Seock Yong; Park, Yong Sun
European Journal of Organic Chemistry, 2012 , # 9 p. 1703 - 1706
反应条件
SPB; water in tetrahydrofuran T=22°C;
参考文献
Angewandte Chemie, International Edition, , vol. 48, # 33 p. 6062 - 6064
Angewandte Chemie, , vol. 121, # 33 p. 6178 - 6180
反应条件
lipase LIP in octane T=30°C; 0.15 h; Yields of byproduct given;
参考文献
Kato; Katayama; Gautam; Fujii; Kimoto
Bioscience, Biotechnology and Biochemistry, 1995 , vol. 59, # 2 p. 271 - 276
反应条件
1: With benzo[1,3,2]dioxaborole; rhodium complex 2 in toluene T=20°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; water; dihydrogen peroxide in toluene T=20°C; Oxidation; 2 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
反应条件
Candida antarctica lipase B in diethyl ether T=20°C; Enzymatic reaction;
参考文献
Tetrahedron Letters, , vol. 45, # 3 p. 627 - 630
反应条件
sodium formate; N-hexadecyl-N,N,N-trimethylammonium bromide; [RuCl(η6-p-cymene)(N-tosyl-1,2-diphenylethylenediamine)] in water T=28°C; 10 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 70, # 23 p. 9424 - 9429
反应条件
N-ethyl-N,N-diisopropylamine; CF3-PIP in chloroform T=0°C; 8 - 10.25 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2005/256150 A1, ;
Page/Page column 15; 16; 18-19 ;
