3-(6-氯-3-吡啶)-丙烯酸乙酯合成路线 （共 8 条）
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; sodium acetate in N,N-dimethyl-formamide T=135°C; Heck-type olefination; 12 h;
参考文献
Na, Youngim; Park, Soyoung; Han, Soo Bong; Han, Hoon; Ko, Sangwon; Chang, Sukbok
Journal of the American Chemical Society, 2004 , vol. 126, # 1 p. 250 - 258
反应条件
1: (ethoxycarbonylmethyl)-triphenylphosphonium bromide With sodium hydride; dimethyl sulfoxide T=0 - 20°C; 0.5 h; 2: 6-chloro-pyridin-3-ylcarboxaldehyde in dimethyl sulfoxide T=0 - 20°C; 1 h;
参考文献
CHDI FOUNDATION, INC.; LUCKHURST, Christopher A.; HAUGHAN, Alan F.; BRECCIA, Perla; STOTT, Andrew J.; BURLI, Roland W.; HUGHES, Samantha J.; MUNOZ-SANJUAN, Ignacio; DOMINGUEZ, Celia; MANGETTE, John E.
Patent: WO2012/103008 A1, 2012 ;
Location in patent: Page/Page column 115; 126 ;
WO 2012/103008 A1
反应条件
tributyl-amine; ammonium chloride; palladium diacetate in water; N,N-dimethyl-formamide
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With potassium tert-butylate in tetrahydrofuran 1 h; Inert atmosphere; 2: 6-chloro-pyridin-3-ylcarboxaldehyde in tetrahydrofuran T=0°C; 1 h; Inert atmosphere;
参考文献
Otrubova, Katerina; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1079 - 1089
反应条件
1.1: 92 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.33 h / -15 °C 2.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C 2.2: 1,2-dimethoxy-ethane / 0.25 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 5 p. 694 - 707
反应条件
in acetonitrile 10 h; Heating;
参考文献
Pandey, Ganesh; Bagul, Trusar D.; Sahoo, Akhil K.
Journal of Organic Chemistry, 1998 , vol. 63, # 3 p. 760 - 768
反应条件
1.1: Et3N / tetrahydrofuran / 0.25 h / -15 °C 2.1: NaBH4 / H2O / 0.33 h / -15 °C 3.1: 92 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / 0.33 h / -15 °C 4.1: NaH / 1,2-dimethoxy-ethane / 0.25 h / 0 °C 4.2: 1,2-dimethoxy-ethane / 0.25 h / 0 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 5 p. 694 - 707
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / |Inert atmosphere 2.1: pyridinium chlorochromate / dichloromethane / 3 h / 0 °C / |Inert atmosphere 3.1: potassium tert-butylate / tetrahydrofuran / 1 h / |Inert atmosphere 3.2: 1 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 57, # 3 p. 1079 - 1089
