(2S,1’R,2’S)-N-(叔丁氧基羰基)-2-(1’-羟基-2’-甲基-3’-丁烯)-吡咯烷合成路线 （共 9 条）
反应条件
tetra-(n-butyl)ammonium iodide in dichloromethane; water T=20°C; 0.333333 h;
参考文献
Cella, Rodrigo; Venturoso, Raphael C.; Stefani, Helio A.
Tetrahedron Letters, 2008 , vol. 49, # 1 p. 16 - 19
反应条件
in tetrahydrofuran 3 h; Ambient temperature;
参考文献
Roux, Florence; Maugras, Isabelle; Poncet, Joel; Niel, Gilles; Jouin, Patrick
Tetrahedron, 1994 , vol. 50, # 18 p. 5345 - 5360
反应条件
1: 82 percent / BOP, DIEA / CH2Cl2 2: 89 percent / AlLiH4 / tetrahydrofuran / 1 h / Ambient temperature 3: 72 percent / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Roux, Florence; Maugras, Isabelle; Poncet, Joel; Niel, Gilles; Jouin, Patrick
Tetrahedron, 1994 , vol. 50, # 18 p. 5345 - 5360
反应条件
1: 89 percent / AlLiH4 / tetrahydrofuran / 1 h / Ambient temperature 2: 72 percent / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Roux, Florence; Maugras, Isabelle; Poncet, Joel; Niel, Gilles; Jouin, Patrick
Tetrahedron, 1994 , vol. 50, # 18 p. 5345 - 5360
反应条件
in tetrahydrofuran T=-78°C; 3 h; Yield given. Yields of byproduct given;
参考文献
Niel, Gilles; Roux, Florence; Maisonnasse, Ysadora; Maugras, Isabelle; Poncet, Joel; Jouin, Patrick
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1275 - 1280
反应条件
4 A molecular sieve in tetrahydrofuran 14 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Niel, Gilles; Roux, Florence; Maisonnasse, Ysadora; Maugras, Isabelle; Poncet, Joel; Jouin, Patrick
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1275 - 1280
反应条件
in tetrahydrofuran T=-78°C; 3 h; diastereoselectivity; further chiral and achiral (Z)-crotylorganoboron compounds; Product distribution;
参考文献
Niel, Gilles; Roux, Florence; Maisonnasse, Ysadora; Maugras, Isabelle; Poncet, Joel; Jouin, Patrick
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1275 - 1280
反应条件
in tetrahydrofuran 60 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Niel, Gilles; Roux, Florence; Maisonnasse, Ysadora; Maugras, Isabelle; Poncet, Joel; Jouin, Patrick
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1275 - 1280
反应条件
1: 90 percent / NaH / dimethylformamide / 24 h / Ambient temperature 2: NaIO4, 60 percent aq. RuO2 / acetonitrile; CCl4 / 6 h 3: 1 M KMnO4 / 2-methyl-propan-2-ol / 0.25 h View Scheme
参考文献
PFIZER INC.; DOROSKI, Matthew David; MADERNA, Andreas; O'DONNELL, Christopher John; SUBRAMANYAM, Chakrapani; VETELINO, Beth Cooper; DUSHIN, Russell George; STROP, Pavel; GRAZIANI, Edmund, Idris
Patent: WO2013/72813 A2, 2013 ;
