13-{[(3-N-叔丁氧羰基)-2,2-二甲基-4S-苯基-1,3-恶唑烷-5R-基]甲酰基}-10-去乙酰基浆果赤霉素III合成路线 （共 3 条）
反应条件
1: 10-deacetylbaccatin III-13-O-[(4S,5R)-4-phenyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine-5-carboxylate] With formic acid T=15 - 20°C; 1.5 h; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in ethyl acetate T=25 - 30°C; pH=7.5 - 8.5; 1.16667 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2009/6590 A2, 2009 ;
Location in patent: Page/Page column 30; 31 ;
反应条件
1: formic acid / 15 - 20 °C 2: sodium hydrogencarbonate / water; ethyl acetate / 25 - 30 °C / pH 7.5 - 8.5 View Scheme
参考文献
Sekhar; Vishweshwar, Peddy; Acharyulu, Palle V. R.; Anjaneyulu, Yerramilli
Synthetic Communications, 2012 , vol. 42, # 23 p. 3482 - 3492
反应条件
Stage #1: With acetic acid T=26°C; 0.166667 h; Stage #2: With zinc in methanol T=55 - 58°C; 0.333333 h; Show Experimental Procedure
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC. Patent: WO2007/109654 A2, 2007 ; Location in patent: Page/Page column title page; 30; 1/31 ;
