4-(溴甲基)哌啶甲酸苄酯合成路线 （共 4 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 5 h;
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Hase, Yasunori; Uchida, Itsuo; Aisaka, Kazuo; Katoh, Susumu; Cho, Hidetsura
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3586 - 3604
反应条件
lithium bromide in tetrahydrofuran; water; ethyl acetate
反应条件
triphenylphosphine in dichloromethane
参考文献
US6562828 B1, ;
US 6562828 B1
反应条件
1.1: isobutyl chloroformate; Et3N / tetrahydrofuran / 0.33 h / -15 °C 1.2: NaBH4 / tetrahydrofuran / 2 h / 20 °C 2.1: 91 percent / CBr4; PPh3 / CH2Cl2 / 5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 10 p. 3586 - 3604
