1,4-二氯-6-硝基二氮杂萘合成路线 （共 2 条）
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in dichloromethane T=85°C; 3 h;
参考文献
FOREST LABORATORIES HOLDINGS LIMITED
Patent: WO2008/61108 A2, 2008 ;
Location in patent: Page/Page column 53 ;
反应条件
1: NH2-NH2*H2O / ethanol / 5 h / Ambient temperature 2: POCl3, i-PrEtN / 3 h / Heating View Scheme
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
